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Updated: Mar 11, 2026

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
How do we recognize the child with OSAS?
Koen F Joosten1, Helena Larramona2, Silvia Miano3
1Erasmus MC, Pediatric Intensive Care, Sophia Children's Hospital, Rotterdam, The Netherlands.
Insights
Childhood obstructive sleep apnea syndrome (OSAS) presents with varied symptoms and risk factors. Diagnosis relies on polysomnography, but oximetry and questionnaires can identify high-risk children when it
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Otolaryngology
Background:
- Obstructive sleep-disordered breathing (SDB) encompasses primary snoring to obstructive sleep apnea syndrome (OSAS) in children.
- Clinical suspicion for OSAS arises from parental reports of symptoms and physical exam findings indicating upper airway obstruction.
- Symptoms include snoring, apneic events, daytime sleepiness, hyperactivity, poor school performance, growth issues, and enuresis.
Purpose of the Study:
- To review the clinical spectrum, diagnosis, and management of obstructive sleep-disordered breathing in children.
- To highlight risk factors and diagnostic challenges, particularly in resource-limited settings.
Main Methods:
- Review of clinical presentations, risk factors, and diagnostic modalities for childhood OSAS.
- Discussion of polysomnography as the gold standard, with alternatives like nocturnal oximetry and sleep questionnaires.
- Inclusion of upper airway endoscopy and MRI for identifying obstruction levels.
Main Results:
- Childhood OSAS has diverse symptoms and risk factors, including prematurity, family history, obesity, and African American ethnicity.
- Polysomnography is definitive but not always feasible; oximetry and questionnaires serve as screening tools.
- Endoscopy and MRI aid in localizing airway obstruction in complex cases.
Conclusions:
- Childhood OSAS is a spectrum of SDB with significant clinical manifestations and morbidities.
- Accurate diagnosis requires considering clinical suspicion, risk factors, and available diagnostic tools, adapting to resource availability.
- Further investigation with imaging may be necessary for complex cases to guide treatment.
Abstract:
Obstructive sleep-disordered breathing includes a spectrum of clinical entities with variable severity ranging from primary snoring to obstructive sleep apnea syndrome (OSAS). The clinical suspicion for OSAS is most often raised by parental report of specific symptoms and/or abnormalities identified by the physical examination which predispose to upper airway obstruction (e.g., adenotonsillar hypertrophy, obesity, craniofacial abnormalities, neuromuscular disorders). Symptoms and signs of OSAS are classified into those directly related to the intermittent pharyngeal airway obstruction (e.g., parental report of snoring, apneic events) and into morbidity resulting from the upper airway obstruction (e.g., increased daytime sleepiness, hyperactivity, poor school performance, inadequate somatic growth rate or enuresis). History of premature birth and a family history of OSAS as well as obesity and African American ethnicity are associated with increased risk of sleep-disordered breathing in childhood. Polysomnography is the gold standard method for the diagnosis of OSAS but may not be always feasible, especially in low-income countries or non-tertiary hospitals. Nocturnal oximetry and/or sleep questionnaires may be used to identify the child at high risk of OSAS when polysomnography is not an option. Endoscopy and MRI of the upper airway may help to identify the level(s) of upper airway obstruction and to evaluate the dynamic mechanics of the upper airway, especially in children with combined abnormalities. Pediatr Pulmonol. 2017;52:260-271. © 2016 Wiley Periodicals, Inc.
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