Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

18.8K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
18.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondrial Responses to Conventional and Ultra-high Dose Rate (FLASH) Radiation.

International journal of radiation oncology, biology, physics·2026
Same author

Addition of Metastasis-Directed Therapy to Standard of Care for Oligometastatic Disease: Primary Aggregated Analysis of All Baskets from the Phase II Randomized EXTEND Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

Metabolic underpinnings of cuproptosis.

Cell chemical biology·2026
Same author

FLASH Radiotherapy Mitigates Radiation-Induced Lymphopenia and Prevents Immunosuppression via Chk1-STAT3 Axis Modulation in a Preclinical Thoracic Irradiation Model.

International journal of radiation oncology, biology, physics·2026
Same author

DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer.

Cancer research·2026
Same author

Clinicogenomic and Histopathologic Analyses of Supermassive Intrahepatic Cholangiocarcinoma and the Role of Ablative Radiotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research·2026

Related Experiment Video

Updated: Mar 11, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

15.1K

Central liver toxicity after SBRT: An expanded analysis and predictive nomogram.

Diego A S Toesca1, Evan C Osmundson2, Rie von Eyben1

  • 1Radiation Oncology Department, Stanford University School of Medicine, United States.

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
|November 21, 2016
PubMed
Summary

Stereotactic body radiation therapy (SBRT) central biliary tract (cHBT) doses correlate with hepatobiliary toxicity (HBT) in primary liver cancer (PLC) patients. Limiting cHBT dose may reduce HBT risk.

Keywords:
BiliaryLiverNomogramSBRTStereotacticToxicity

More Related Videos

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.3K
Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.8K

Related Experiment Videos

Last Updated: Mar 11, 2026

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy
08:54

Treatment of Liver Metastases Using an Internal Target Volume Method for Stereotactic Body Radiotherapy

Published on: May 8, 2018

15.1K
Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy
08:17

Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

Published on: June 7, 2015

16.3K
Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

18.8K

Area of Science:

  • Radiation Oncology
  • Hepatobiliary Surgery
  • Medical Physics

Background:

  • Stereotactic body radiation therapy (SBRT) is increasingly used for liver tumors.
  • Hepatobiliary toxicity (HBT) is a significant concern following SBRT.
  • The central biliary tract (cHBT) is a critical structure for dose assessment.

Purpose of the Study:

  • To investigate the relationship between cHBT radiation doses and HBT after SBRT.
  • To analyze this correlation in a larger patient cohort.
  • To identify dose constraints for reducing HBT risk.

Main Methods:

  • Retrospective review of 130 patients treated with SBRT for primary or metastatic liver tumors.
  • cHBT defined as isotropic expansions (5-25mm) from the portal vein.
  • Doses converted to biologically effective doses (BED10); HBT graded using CTCAE v4.03.

Main Results:

  • HBT occurred in 25.4% (grade 2+) and 21.5% (grade 3+).
  • Grade 3+ HBT was more frequent in cholangiocarcinoma (50%) than HCC (17.5%) or metastases (11.7%).
  • SBRT doses to the cHBT strongly correlated with HBT specifically in primary liver cancer (PLC) patients.

Conclusions:

  • cHBT radiation doses are associated with HBT occurrence exclusively in PLC patients.
  • The 15mm expansion from the portal vein (cHBT15) is a suitable surrogate.
  • Limiting cHBT15 dose to VBED1040<37cc and VBED1030<45cc may mitigate HBT risk.