Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stages of Infection01:26

Stages of Infection

66.4K
Stages of infection describe what happens to a susceptible host once a pathogen invades the human body. The stages of infection are incubation, prodromal, illness, stage of decline, and convalescence. The incubation stage is the period from exposure to a pathogen until symptoms start. The infected person is unaware of impending illness as the pathogens grow and multiply within the body. The duration may vary depending on the type of infection. The incubation period of measles averages ten to...
66.4K
Transition Zone01:28

Transition Zone

445
The transition zone in concrete is a critical area where aggregate meets cement paste, marked by a distinct porosity and weakness compared to the surrounding material. The adhesion around the aggregates is primarily due to Van Der Waals forces. The voids within this zone influence its robustness; initially, it is less durable than the surrounding bulk mortar due to larger voids. Initially, when concrete is compacted, a higher water-cement ratio near the aggregates leads to the formation of...
445
Crossing over01:34

Crossing over

13.1K
13.1K
Crossing Over01:30

Crossing Over

7.0K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
7.0K
Crossing Over01:34

Crossing Over

173.5K
Unlike mitosis, meiosis aims for genetic diversity in its creation of haploid gametes. Dividing germ cells first begin this process in prophase I, where each chromosome—replicated in S phase—is now composed of two sister chromatids (identical copies) joined centrally.
The homologous pairs of sister chromosomes—one from the maternal and one from the paternal genome—then begin to align alongside each other lengthwise, matching corresponding DNA positions in a process...
173.5K
Kubler Ross's Stages of Dying01:21

Kubler Ross's Stages of Dying

1.6K
Elisabeth Kübler-Ross significantly advanced psychology's understanding of the process of dying with her influential book, On Death and Dying (1969). She focused on studying terminally ill individuals and outlined five stages commonly experienced when coping with death: denial, anger, bargaining, depression, and acceptance.
In denial, individuals reject the reality of their condition, often thinking, "This isn't true; I feel fine," as a way to protect themselves from...
1.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Intraoperative mobile CT and virtual-assisted lung mapping for pulmonary nodule localization: workflow characteristics and radiation dosage in a single-center experience.

General thoracic and cardiovascular surgery·2026
Same author

Main pulmonary artery reconstruction during lung transplantation for idiopathic pulmonary artery hypertension with giant pulmonary artery aneurysm.

JTCVS techniques·2026
Same author

Revisiting static ice storage in clinical lung transplantation: Direct and continuous temperature monitoring of donor lungs followed by mathematical modeling.

JHLT open·2026
Same author

Prognostic impact of the C-reactive protein-albumin-lymphocyte index in patients with resected lung cancer associated with interstitial pneumonia.

Surgery today·2026
Same author

Impact of flat chest on waitlist mortality in adult patients with pleuroparenchymal fibroelastosis listed for lung transplantation.

JHLT open·2026
Same author

Significance of geriatric nutritional risk index in predicting lung-transplant waiting list mortality of patients with interstitial lung disease regardless of percentage forced vital capacity.

General thoracic and cardiovascular surgery·2026

Related Experiment Video

Updated: Mar 11, 2026

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios
07:43

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios

Published on: August 4, 2023

2.8K

W'ALK' Into the Next Stage.

Gouji Toyokawa1, Takashi Seto2, Mitsuhiro Takenoyama2

  • 1Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan; Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Clinical Lung Cancer
|November 21, 2016
PubMed
Summary

Anaplastic lymphoma kinase (ALK) rearrangements drive a subset of non-small-cell lung cancer (NSCLC). While ALK inhibitors (ALKis) have advanced treatment, further research is needed to optimize sequencing and combination therapies for improved patient survival.

Keywords:
Anaplastic lymphoma kinase (ALK)Antiangiogenic therapyCytotoxic chemotherapyImmune checkpoint therapySequential therapy with ALK inhibitors

More Related Videos

Simultaneous Scalp Electroencephalography EEG, Electromyography EMG, and Whole-body Segmental Inertial Recording for Multi-modal Neural Decoding
11:25

Simultaneous Scalp Electroencephalography EEG, Electromyography EMG, and Whole-body Segmental Inertial Recording for Multi-modal Neural Decoding

Published on: July 26, 2013

44.2K
Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior
06:38

Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior

Published on: June 9, 2020

5.4K

Related Experiment Videos

Last Updated: Mar 11, 2026

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios
07:43

Author Spotlight: A Novel Setup to Conduct Naturalistic Laboratory Experiments with Real Human Actors in Scenarios

Published on: August 4, 2023

2.8K
Simultaneous Scalp Electroencephalography EEG, Electromyography EMG, and Whole-body Segmental Inertial Recording for Multi-modal Neural Decoding
11:25

Simultaneous Scalp Electroencephalography EEG, Electromyography EMG, and Whole-body Segmental Inertial Recording for Multi-modal Neural Decoding

Published on: July 26, 2013

44.2K
Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior
06:38

Using a Virtual Reality Walking Simulator to Investigate Pedestrian Behavior

Published on: June 9, 2020

5.4K

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Anaplastic lymphoma kinase (ALK) rearrangement is a key driver in a subset of non-small-cell lung cancer (NSCLC).
  • The development of ALK inhibitors (ALKis) has revolutionized treatment for ALK-rearranged NSCLC.
  • Understanding resistance mechanisms and optimizing therapeutic strategies remain critical.

Purpose of the Study:

  • To review the current landscape of ALK-rearranged NSCLC treatment.
  • To identify unmet needs and future directions in ALK inhibitor therapy.
  • To explore optimal sequencing and combination strategies for prolonged survival.

Main Methods:

  • Literature review of ALK rearrangements in NSCLC.
  • Analysis of clinical trial data for ALK inhibitors.
  • Discussion of resistance mechanisms and emerging therapies.

Main Results:

  • ALK inhibitors have shown significant efficacy, including in brain metastases.
  • Various resistance mechanisms to ALKis have been identified and addressed.
  • Next-generation ALKis offer improved outcomes over first-generation agents.

Conclusions:

  • Despite advances, optimal sequencing of ALKis requires further investigation.
  • The role of antiangiogenic therapy, immunotherapy, and chemotherapy in combination with ALKis needs clarification.
  • Further research is essential to establish definitive treatment strategies and improve survival for ALK-rearranged NSCLC patients.