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Ghost Cell Tumors.

Jason Sheikh1, Molly D Cohen2, Naomi Ramer3

  • 1Former Resident, Mount Sinai Medical Center, New York, NY; Fellow, Cleft and Craniomaxillofacial Surgery, Charleston Area Medical Center, Charleston, WV.

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
|November 21, 2016
PubMed
Summary

This study presents two rare ghost cell tumors: calcifying cystic odontogenic tumor (CCOT) and peripheral dentinogenic ghost cell tumor (DGCT). Both cases were successfully treated with surgical intervention and showed no recurrence.

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Area of Science:

  • Oral pathology
  • Odontogenic neoplasms
  • Oncology

Background:

  • Ghost cell tumors encompass a spectrum of lesions, from cystic to solid, with varying behavior from benign to metastatic.
  • All ghost cell tumors share characteristic features: ameloblastic epithelium, ghost cells, and calcifications.

Observation:

  • A 14-year-old girl presented with a calcifying cystic odontogenic tumor (CCOT) in the mandible, exhibiting pain and swelling.
  • A 65-year-old woman had a peripheral dentinogenic ghost cell tumor (DGCT) with dysplastic changes, also presenting with mandibular pain and swelling.
  • Radiographic examination in both cases revealed mixed radiolucent and radiopaque lesions.

Findings:

  • Biopsy confirmed CCOT in the first patient, who underwent decompression, enucleation, and bone grafting.
  • Biopsy suggested DGCT in the second patient, treated with excision and peripheral ostectomy.
  • Both patients showed no evidence of recurrence at 6 and 12-month follow-ups.

Implications:

  • This report highlights successful management strategies for rare ghost cell tumors of the jaw.
  • Early diagnosis and appropriate surgical intervention are crucial for favorable outcomes in CCOT and DGCT.
  • The findings contribute to understanding the clinical presentation and treatment of these odontogenic neoplasms.