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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

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Chronic Obstructive Pulmonary Disease01:24

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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
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Interstitial Lung Disease in the Elderly.

Karen C Patterson1, Rupal J Shah2, Mary K Porteous1

  • 1Pulmonary, Allergy & Critical Care Division, University of Pennsylvania, Pennsylvania, PA.

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|November 21, 2016
PubMed
Summary
This summary is machine-generated.

Interstitial lung disease (ILD) in elderly patients (≥70 years) often presents as unclassifiable ILD or idiopathic pulmonary fibrosis (IPF). However, ILD in this age group is not more severe, with similar outcomes to younger patients.

Keywords:
agingelderlyidiopathic pulmonary fibrosisinterstitial lung disease

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Area of Science:

  • Pulmonology
  • Geriatric Medicine
  • Epidemiology

Background:

  • Idiopathic pulmonary fibrosis (IPF) is linked to aging, but the epidemiology of interstitial lung disease (ILD) in the elderly remains poorly understood.
  • This study focuses on the diagnoses, clinical characteristics, and outcomes of elderly patients diagnosed with ILD.

Purpose of the Study:

  • To investigate the epidemiology of ILD in elderly individuals (age ≥ 70 years).
  • To compare the diagnoses, clinical features, and outcomes of elderly ILD patients with non-elderly counterparts.

Main Methods:

  • Analysis of a prospective cohort study of ILD patients, defining elderly as age ≥ 70 years.
  • Diagnoses were determined through multidisciplinary review.
  • Statistical analysis (chi-squared test, ANOVA) compared elderly and non-elderly groups.

Main Results:

  • Elderly individuals constituted 24% of the 327 enrolled subjects.
  • The most frequent diagnoses in the elderly were unclassifiable ILD (45%) and IPF (34%).
  • No significant differences in pulmonary function or 3-year mortality were observed between elderly and non-elderly groups, including IPF subgroups.

Conclusions:

  • While IPF is common, most elderly ILD cases are non-IPF, with unclassifiable ILD being frequent.
  • The study emphasizes screening for connective tissue disease (CTD) in all new ILD cases.
  • ILD severity and aggressiveness were not greater in the elderly compared to younger individuals.