Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

5.8K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.8K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

1.9K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[ATM/H2AX and repair of sperm-DNA damage during cryopreservation].

Zhonghua nan ke xue = National journal of andrology·2011
Same author

Predicting accident frequency at their severity levels and its application in site ranking using a two-stage mixed multivariate model.

Accident; analysis and prevention·2011
Same author

Photothermally enhanced photodynamic therapy delivered by nano-graphene oxide.

ACS nano·2011
Same author

[Characteristics of soil respiration in Phyllostachys edulis forest in Wanmulin Natural Reserve and related affecting factors].

Ying yong sheng tai xue bao = The journal of applied ecology·2011
Same author

Quality changes in sea urchin (Strongylocentrotus nudus) during storage in artificial seawater saturated with oxygen, nitrogen and air.

Journal of the science of food and agriculture·2011
Same author

Global effect of an RNA polymerase β-subunit mutation on gene expression in the radiation-resistant bacterium Deinococcus radiodurans.

Science China. Life sciences·2011
Same journal

Dynorphinergic neuroadaptations in the islands of Calleja: implications for alcohol use disorder.

Neuroscience letters·2026
Same journal

Differential vulnerability of cochlear nuclei to Lmx1 deficiency: abnormal patterning and implications for auditory circuitry.

Neuroscience letters·2026
Same journal

Role of nNOS/sGC pathway in the insular cortex in control of cardiovascular, autonomic and corticosterone responses to restraint stress in rats.

Neuroscience letters·2026
Same journal

Jak1 inhibition reduces acute allodynia induced by specific upstream cytokines in rats: implications for the onset of Jak1 pain modulation.

Neuroscience letters·2026
Same journal

Glucocorticoids-induced depressive-like behaviors in mice: oral ingestion of corticosterone or hydrocortisone - A comparative study.

Neuroscience letters·2026
Same journal

Data-driven clustering of prefrontal activation identifies functional phenotypes under prioritized dual-task walking conditions in Parkinson's disease.

Neuroscience letters·2026
See all related articles

Related Experiment Video

Updated: Mar 11, 2026

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
10:56

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

13.6K

Bone marrow mesenchymal stem cells decrease CHOP expression and neuronal apoptosis after spinal cord injury.

Chuanlong Gu1, Heyangzi Li1, Chao Wang1

  • 1Department of Basic Medicine Sciences, School of Medicine, Zhejiang University, Hangzhou 310058, China.

Neuroscience Letters
|November 21, 2016
PubMed
Summary
This summary is machine-generated.

Bone marrow derived mesenchymal stem cells (BMSCs) improve recovery after spinal cord injury (SCI) by reducing neuronal apoptosis. BMSCs protect motor neurons by decreasing the expression of the pro-apoptotic factor CHOP.

Keywords:
ApoptosisBone marrow mesenchymal stem cellsC/EBP homology proteinEndoplasmic reticulum stressSpinal cord injury

More Related Videos

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells
10:16

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells

Published on: June 14, 2017

7.8K
A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury
09:08

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

Published on: September 13, 2018

10.4K

Related Experiment Videos

Last Updated: Mar 11, 2026

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
10:56

Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury

Published on: December 17, 2014

13.6K
Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells
10:16

Hypoxic Preconditioning of Marrow-derived Progenitor Cells As a Source for the Generation of Mature Schwann Cells

Published on: June 14, 2017

7.8K
A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury
09:08

A Neurosphere Assay to Evaluate Endogenous Neural Stem Cell Activation in a Mouse Model of Minimal Spinal Cord Injury

Published on: September 13, 2018

10.4K

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Spinal cord injury (SCI) causes irreversible neuronal damage and paralysis.
  • Bone marrow derived mesenchymal stem cells (BMSCs) show promise for SCI treatment.
  • Understanding the protective mechanisms of BMSCs is crucial for therapeutic development.

Purpose of the Study:

  • To investigate the therapeutic effects of BMSCs in a rat model of SCI.
  • To examine the impact of BMSCs on motor neuron apoptosis under oxygen-glucose deprivation (OGD) conditions.
  • To elucidate the role of C/EBP homologous protein (CHOP) in BMSC-mediated neuroprotection.

Main Methods:

  • Treatment of rats with SCI using BMSCs.
  • In vitro study of OGD-treated motor neurons co-cultured with BMSCs or BMSC-conditioned medium.
  • Assessment of locomotor function and apoptosis markers, including CHOP expression.

Main Results:

  • BMSCs significantly improved locomotor function in rats with SCI.
  • BMSC treatment reduced apoptosis and CHOP expression in injured spinal cords.
  • BMSCs and their conditioned medium decreased CHOP expression and apoptosis in OGD-treated motor neurons.

Conclusions:

  • BMSCs exert neuroprotective effects in SCI by reducing motor neuron apoptosis.
  • The mechanism involves the downregulation of the pro-apoptotic transcription factor CHOP.
  • These findings support BMSCs as a potential therapeutic strategy for SCI.