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The CD4/CD8 ratio is associated with coronary artery disease (CAD) in elderly Chinese patients

Pan Gao1, Hong-Hui Rong2, Ting Lu1

  • 1Department of Geriatrics, The First Affiliated Hospital to Third Military Medical University, Southwest Hospital, Chongqing, China.

International Immunopharmacology
|November 21, 2016
PubMed

Insights

The ratio of CD4 to CD8 T cells is strongly linked to coronary artery disease (CAD) in older Chinese adults. A higher CD4/CD8 ratio independently predicts increased CAD risk in this population.

Area of Science:

  • Immunology
  • Cardiology
  • Geriatrics

Background:

  • Coronary artery disease (CAD) is a significant health concern in elderly populations.
  • T cells play a role in immune responses and inflammation, potentially influencing cardiovascular health.

Purpose of the Study:

  • To examine the association between circulating T cell counts and the prevalence of CAD.
  • To identify T cell-related biomarkers for CAD risk in elderly Chinese individuals.

Main Methods:

  • A cross-sectional study involving 295 elderly inpatients (age ≥ 60).
  • Clinical and biochemical data were collected, and patients were categorized into control and CAD groups.
  • Binary logistic regression analysis was used to explore CAD risk factors.

Main Results:

  • The CD4/CD8 T cell ratio was significantly higher in patients with CAD compared to controls.
  • No significant differences were observed in the absolute counts of CD3, CD4, or CD8 T cells between groups.
  • The CD4/CD8 ratio emerged as an independent predictor of CAD, alongside age, gender, BMI, SBP, and CHF.

Conclusions:

  • A strong, independent association exists between the CD4/CD8 T cell ratio and coronary artery disease in the elderly Chinese population.
  • An elevated CD4/CD8 ratio (>1.5) is associated with a significantly increased risk of CAD, even after adjusting for multiple clinical parameters.
Abstract

Keywords:
CD4/CD8Coronary artery diseaseElderly patientsT cells

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