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Published on: July 29, 2014
Effect of magnesium sulfate on morphine activity retention to control pain after herniorrhaphy
Sedigheh Nadri1, Hormoz Mahmoudvand2, Sepideh Vahabi1
1Department of Anesthesiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Aim:
This research was carried out to compare magnesium sulfate (MgSO4) with isotonic saline in terms of pain control after herniorrhaphy.
Patients & Methods:
A randomized double-blind study, in which the patients were blind to all. A total of 100 patients who were candidates of herniorrhaphy were randomized into two groups: experimental and control (50 patients in each). Anesthesia was induced with 20% of 4 cc of morphine. The experimental and control group received postoperative 20% of 2 cc MgSO4 in 2 cc of isotonic saline and 4 cc of isotonic saline, respectively.
Result:
The administration of postoperative morphine in control group 0.79 ± 1.48 mg was significantly higher to the experimental group 0.17 ± 0.63 mg during the first 24 h (p = 0.01).
Conclusion:
MgSO4 increased the potency of morphine thereby reducing the amount of postoperative pain killer needed.
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