[Effects of chronic exposure to monochloroacetic acid on the lung function and lymphocyte subsets in occupational...

Objective: To investigate the effects of chronic exposure to monochloroacetic acid on the lung function and whole blood counts in occupational exposed workers, and provide new markers for occupational health surveillance. Methods: We conducted a cross-sectional molecular epidemiology study of 121 workers who were occupationally exposed to monochloroacetic acid and 69 unexposed workers frequency-matched by age and smoking status from the same geographic region. The lung function was measured by portable lung function instrument, and the lymphocyte subsets were measured by flow cytometry. Linear regression was used to test for differences in the levels of each marker between exposed and control workers. Results: FEV1.0/FVC was significantly decreased in both male and female workers exposed to monochloroacetic acid compared to unexposed workers (P<0.01) after adjusting for potential confounders, which were highly consistent when stratified by smoking status. Among male workers, monochloroacetic acid exposure was associated with significant decrease in the levels of CD8⁺ T cells (P<0.05) and monocytes (P<0.05) , and these statistically significant differences were observed between exposure and control workers only among smokers, not among non-smokers. However, there were no significant differences in the levels of whole blood cells and lymphocyte subsets between two groups among female workers. Conclusion: The chronic monochloroacetic acid exposure was associated with pulmonary dysfunction and immunosuppression, which mainly occurred among male workers and smokers.