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Adequate Vitamin D Intake but Low Serum Levels in Pediatric Asthma Patients: A Pilot Study, Alberta Children's

Sarah Howe McKenna1, Tanis R Fenton2, Mary Noseworthy3

  • 1Alberta Children's Hospital, 2888 Shaganappi Trail NW, Calgary, AB, Canada T3B 6A8; Nutrition Services, Alberta Health Services, Calgary, AB, Canada.

Canadian Respiratory Journal
|November 22, 2016
PubMed

Insights

Pediatric asthma patients had higher vitamin D intake but lower serum levels than healthy children. Monitoring and supplementing vitamin D is crucial for these patients to ensure adequate bone health.

Area of Science:

  • Pediatric Pulmonology
  • Nutritional Science
  • Endocrinology

Background:

  • Asthma management often involves treatments that can affect bone health.
  • Vitamin D status is critical for bone mineral accretion, particularly in children.
  • Previous research has not extensively detailed vitamin D intake and levels in pediatric asthma patients on inhaled steroids.

Purpose of the Study:

  • To assess vitamin D intake and serum 25-hydroxyvitamin D levels in pediatric asthma patients.
  • To compare these levels with those of healthy children in the same geographic region.
  • To inform recommendations for maintaining adequate vitamin D status in children with asthma.

Main Methods:

  • A cohort of pediatric asthma patients (n=20) on moderate-to-high dose inhaled steroids was studied.
  • Vitamin D intake was estimated using a validated food frequency questionnaire.
  • Serum 25-hydroxyvitamin D (25(OH)D) levels were obtained from medical records and compared to published data.

Main Results:

  • Asthma patients reported significantly higher daily vitamin D intake (742 ± 185 IU/day) than healthy children (229 ± 121 IU/day).
  • Despite higher intake, asthma patients showed nonsignificantly lower serum 25(OH)D levels compared to the healthy group.
  • A positive correlation was observed between vitamin D intake and serum 25(OH)D levels (3.6 nmol/L per 100 IU intake, R²=0.931, p=0.001).

Conclusions:

  • Pediatric asthma patients on inhaled steroids may not achieve optimal vitamin D status despite higher intake.
  • Regular monitoring of serum 25(OH)D levels is recommended for children with asthma.
  • Supplementation should be considered to ensure adequate vitamin D status for bone health in this population.

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