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Nitric oxide and hyperoxic acute lung injury

Wen-Wu Liu1, Cui-Hong Han2, Pei-Xi Zhang3

  • 1Department of Diving and Hyperbaric Medicine, Secondary Military Medical University, Shanghai, China.

Medical Gas Research
|November 22, 2016
PubMed

Hyperoxic acute lung injury (HALI) refers to the damage to the lungs secondary to exposure to elevated oxygen partial pressure. HALI has been a concern in clinical practice with the development of deep diving and the use of normobaric as well as hyperbaric oxygen in clinical practice. Although the pathogenesis of HALI has been extensively studied, the findings are still controversial. Nitric oxide (NO) is an intercellular messenger and has been considered as a signaling molecule involved in many physiological and pathological processes. Although the role of NO in the occurrence and development of pulmonary diseases including HALI has been extensively studied, the findings on the role of NO in HALI are conflicting. Moreover, inhalation of NO has been approved as a therapeutic strategy for several diseases. In this paper, we briefly summarize the role of NO in the pathogenesis of HALI and the therapeutic potential of inhaled NO in HALI.

Keywords:
hyperoxiahyperoxic acute lung injuryinhaled nitric oxidenitric oxidenitric oxide synthasenitro-L-arginine methyl esterreactive nitrogen speciesreactive oxygen species

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