Intrathecal/Intraventricular Linezolid in Multidrug-Resistant Enterococcus faecalis Ventriculitis

Area of Science:

• Infectious Diseases
• Neuroscience
• Pharmacology

Background:

• Intrathecal antibiotic therapy is effective for ventriculitis and meningitis when intravenous antibiotics fail.
• Cerebrospinal fluid sterilization remains a challenge in complex cases.
• Multidrug-resistant pathogens necessitate novel therapeutic strategies.

Observation:

• A 32-year-old female patient presented with Enterococcus faecalis ventriculitis.
• The patient had a severe allergy to vancomycin and limited antibiotic options.
• Previous treatments failed to sterilize cerebrospinal fluid despite multimodal approaches.

Findings:

• Successful treatment of ventriculitis was achieved using intrathecal linezolid.
• This case highlights the efficacy of intrathecal linezolid in a vancomycin-allergic patient.
• A practical dosing regimen for intrathecal linezolid administration is provided.

Implications:

• Intrathecal linezolid is a viable option for multidrug-resistant bacterial ventriculitis.
• This approach offers a solution for patients with antibiotic allergies.
• The presented dosing regimen can guide clinical practice for intrathecal linezolid use.