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Impact of short sleep on metabolic variables in obese children with obstructive sleep apnea

Bharat Bhushan1,2, Bushra Ayub1, Dana M Thompson1,2

  • 1Division of Otolaryngology-Head and Neck Surgery, Ann & Robert H. Lurie Children's Hospital of Chicago.

The Laryngoscope
|November 22, 2016
PubMed

Insights

Short sleep duration in obese children is linked to higher triglycerides, blood glucose, and insulin resistance. These metabolic changes may lead to long-term health issues, emphasizing the importance of adequate sleep.

Area of Science:

  • Pediatric Endocrinology
  • Sleep Medicine
  • Metabolic Health

Background:

  • Declining sleep duration correlates with rising obesity and diabetes rates.
  • Understanding the link between sleep, metabolism, and insulin resistance in obese children is crucial.

Purpose of the Study:

  • To investigate the association between sleep duration, metabolic variables, and insulin resistance in obese children.
  • To compare these associations in obese children with and without obstructive sleep apnea.

Main Methods:

  • Retrospective analysis of 171 obese children (3-12 years) who underwent polysomnography (PSG) and metabolic testing.
  • Patients categorized into short, borderline, and optimal sleep duration groups based on PSG and questionnaire data.
  • Metabolic variables including lipids, glucose, insulin, and HOMA-IR were analyzed.

Main Results:

  • Short sleepers (50.3%) showed significantly higher triglycerides, blood glucose, insulin, and HOMA-IR compared to borderline or optimal sleepers.
  • No significant differences were observed in lipid profiles (HDL, LDL, total cholesterol) among sleep groups.
  • BMI z-scores did not differ significantly across sleep duration categories.

Conclusions:

  • Short sleep duration in obese children is associated with adverse metabolic alterations and increased insulin resistance.
  • These findings highlight potential long-term health risks, including the persistence of comorbid conditions into adulthood.
Abstract

Keywords:
Short sleepchildhood obesityinsulin resistanceobstructive sleep apnea

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