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Updated: Aug 12, 2026

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The combined effect of nitrous oxide and oxygen and electrical stimulation during restorative dental treatment
D Donaldson1, F Quarnstrom, J T Jastak
1Department of Medical and Surgical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
Abstract:
A total of 124 adult patients were treated with nitrous oxide (N2O) and oxygen (O2), an electrical analgesic, or a combination of N2O/O2 and an electrical analgesic during restorative dental procedures. The use of electrical analgesic or N2O/O2 without local anesthetics resulted in a high failure rate and poor patient acceptance. However, combining N2O/O2 sedation with electrically induced analgesia resulted in a statistically significant improvement over either technique used alone, and provided an overall 81% success rate when used during restorative dentistry.
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