Exacerbation of bleeding with renal insufficiency

An elderly patient with upper gastrointestinal bleeding of peptic ulcer disease and renal insufficiency was presented. Her bleeding was complicated by an underlying hemostatic defect related to her renal disease and secondary bleeding prolongation. Cryoprecipitate reversed the defect and stopped the clinical bleeding. In the elderly adult population where renal insufficiency and elevated creatinines are more common, it is important to consider the hemostatic defect that may be associated with renal disease and bleeding. Infusion of cryoprecipitate may result in both a delayed correction of the abnormal bleeding time and reversal of clinical bleeding.