Related Experiment Video

Updated: Mar 11, 2026

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

2.0K

Non-alcoholic fatty liver disease: a new epidemic in children

Mirta Ciocca1, Margarita Ramonet2,3, Fernando Álvarez4

  • 1Hepatología y Trasplante Hepático Pediátrico, Hospital Alemán, Ciudad Autónoma de Buenos Aires, Argentina. mciocca@intramed.net.

Archivos Argentinos De Pediatria
|November 22, 2016
PubMed

Insights

Non-alcoholic fatty liver disease (NAFLD) is a common liver condition linked to obesity. Further understanding NAFLD pathogenesis is crucial for developing new therapies and diagnostic tools.

Area of Science:

  • Hepatology
  • Metabolic Disorders
  • Public Health

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is a prevalent liver condition affecting adults and children globally.
  • Obesity is a significant driver of the increasing prevalence of NAFLD worldwide.
  • NAFLD encompasses a spectrum of conditions, from simple steatosis to steatohepatitis with inflammation and fibrosis.

Purpose of the Study:

  • To highlight the current understanding of NAFLD pathogenesis and progression.
  • To emphasize the need for improved diagnostic tools and therapeutic strategies for NAFLD.
  • To underscore the importance of ongoing research in liver disease.

Main Methods:

  • Review of current literature on NAFLD.
  • Analysis of histological findings in NAFLD staging.
  • Discussion of diagnostic and therapeutic approaches.

Main Results:

  • NAFLD is a major cause of chronic liver disease.
  • Pathogenesis and progression of NAFLD require further elucidation.
  • Liver biopsy is the current gold standard for NAFLD staging.

Conclusions:

  • A deeper understanding of NAFLD is essential for advancing treatment and diagnostics.
  • Lifestyle modifications are primary treatments, but pharmacological interventions are needed for some patients.
  • Research into novel drugs offers hope for individuals unresponsive to initial therapies.

Keywords:
Childhood obesityHepatic steatosisNon-alcoholic fatty liver disease

More Related Videos

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.9K
Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution04:14

Incorporation of a Survivable Liver Biopsy Procedure in Mice to Assess Non-alcoholic Steatohepatitis NASH Resolution

Published on: April 16, 2019

12.8K

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
954
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
247
Liver Physiology01:30

Liver Physiology

The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
4.1K
Liver Regeneration01:24

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.6K