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Clinical Experience with Daptomycin in Pediatrics

Katie C Namtu1, Julianna C Crain1, Allison F Messina2

  • 1Department of Pharmacy, Johns Hopkins All Children's Hospital, St. Petersburg, Florida.

Pharmacotherapy
|November 22, 2016
PubMed
Abstract

Insights

Daptomycin effectively treated gram-positive infections in children, with 98% showing improvement. Further trials are needed to confirm safety and efficacy in pediatric patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Antimicrobial Therapy
  • Pharmacology

Background:

  • Emergence of antimicrobial resistance complicates gram-positive infection management.
  • Daptomycin offers a unique mechanism of action and favorable dosing for gram-positive infections.
  • Limited safety, efficacy, and pharmacokinetic data exist for daptomycin in pediatric populations.

Purpose of the Study:

  • To review the clinical experience with daptomycin for gram-positive infections in neonatal and pediatric patients.
  • To assess the safety and efficacy of daptomycin in a pediatric cohort.

Main Methods:

  • Retrospective analysis of electronic medical records.
  • Inclusion of hospitalized children receiving daptomycin for proven gram-positive infections (October 2008 - June 2014).
  • Analysis of patient demographics, infection types, treatment duration, clinical outcomes, and creatine phosphokinase (CPK) levels.

Main Results:

  • 109 pediatric patients with proven gram-positive infections were analyzed.
  • Catheter-related bloodstream infections were most common (n=81).
  • 98% of patients showed clinical improvement; 3 patients had elevated CPK levels.

Conclusions:

  • Daptomycin demonstrated clinical improvement in the majority of pediatric patients with gram-positive infections.
  • Further randomized controlled trials are essential to establish daptomycin's safety and efficacy in pediatric populations.
  • Daptomycin shows promise as a treatment option for pediatric gram-positive infections.
Keywords:
antibioticsantimicrobialsdaptomycingram-positive infectionspediatrics

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