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Sex/gender influences on the nervous system: Basic steps toward clinical progress.
Claudette Elise Brooks1, Janine Austin Clayton1
1Office of Research on Women's Health (ORWH), Office of the Director, National Institutes of Health, Bethesda, Maryland.
Journal of Neuroscience Research
|November 22, 2016
Summary
Sex-based research in neuroscience is advancing, revealing complexities and informing clinical trials. Integrating both sexes in preclinical studies builds essential knowledge for future research and applications.
Area of Science:
- Neuroscience
- Sex as a biological variable research
Background:
- Sex-based data is increasingly recognized as crucial in understanding neurological processes.
- Previous research has laid the groundwork for incorporating sex as a biological variable.
Purpose of the Study:
- To highlight advancements in sex-based neuroscience research.
- To discuss the complexities revealed by incorporating sex as a biological variable.
- To emphasize the role of this research in informing clinical trial design.
Main Methods:
- Review and commentary on existing sex-based neuroscience research.
- Analysis of the implications of integrating sex as a biological variable in preclinical studies.
Main Results:
- Significant progress has been made in sex-based neuroscience.
- Research integrating both sexes reveals complex biological differences.
- This approach is foundational for future neuroscience.
Conclusions:
- Continued focus on sex as a biological variable in neuroscience is essential.
- Integrating studies of both sexes in preclinical research will significantly inform clinical trial design.
- The expansion of knowledge in this area is critical for advancing neuroscience applications.
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