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Mindfulness-Based Cognitive Therapy in Advanced Prostate Cancer: A Randomized Controlled Trial
Suzanne K Chambers1, Stefano Occhipinti1, Elizabeth Foley1
1Suzanne K. Chambers, Stefano Occhipinti, Melissa Legg, and David P. Smith, Griffith University, Gold Coast; Suzanne K. Chambers, Samantha Clutton, Melissa Legg, Cancer Council Queensland; Robert A. Gardiner, University of Queensland, Brisbane; Suzanne K. Chambers, University of Southern Queensland, Toowoomba, Queensland; Suzanne K. Chambers, Prostate Cancer Foundation of Australia; Suzanne K. Chambers, Stefano Occhipinti, Samantha Clutton, Melissa Legg, Martin Berry, Martin R. Stockler, Mark Frydenberg, Robert A. Gardiner, Ian D. Davis, and David P. Smith, Australian and New Zealand Urogenital and Prostate Cancer Trials Group; Elizabeth Foley, Mind Potential; Martin R. Stockler, and David P. Smith, University of Sydney; David P. Smith, Cancer Council New South Wales, Sydney; Martin Berry, Central Coast Cancer Centre, Gosford; Martin R. Stockler, Concord Repatriation General Hospital, Concord, New South Wales; Suzanne K. Chambers, Robert A. Gardiner, Edith Cowan University, Perth, Western Australia; Mark Frydenberg, Monash Health; Mark Frydenberg, Ian D. Davis, Monash University; Ian D. Davis, Eastern Health, Melbourne, Victoria, Australia; and Stephen J. Lepore, Temple University, Philadelphia, PA.
Mindfulness-based cognitive therapy (MBCT) did not significantly reduce distress in men with advanced prostate cancer (PC). Future research should explore interventions better suited to male patients.
Area of Science:
- Oncology
- Psychology
- Behavioral Medicine
Background:
- Advanced prostate cancer (PC) significantly impacts patients' psychosocial well-being.
- Effective interventions are needed to manage distress in this population.
Purpose of the Study:
- To evaluate the effectiveness of mindfulness-based cognitive therapy (MBCT) in reducing psychological and cancer-specific distress in men with advanced PC.
- To assess MBCT's impact on prostate-specific antigen anxiety and mindfulness skills.
Main Methods:
- A randomized controlled trial comparing an 8-week telephone-delivered MBCT intervention to usual care in men with advanced PC.
- Intention-to-treat and per-protocol analyses were conducted over a 9-month follow-up period.
- Primary outcomes included psychological distress, cancer-specific distress, and prostate-specific antigen anxiety.
Main Results:
- No significant differences in primary outcomes were observed between the MBCT and usual care groups.
- Per-protocol analysis showed a significant increase in the mindfulness skill of 'observing' in the MBCT group (P = .032).
- Facilitator adherence to the MBCT protocol was high (>93%).
Conclusions:
- Telephone-delivered MBCT was not more effective than minimally enhanced usual care for reducing distress in men with advanced PC.
- Future interventions should consider approaches that align better with male patients' needs and cultural contexts.
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