RELATIONSHIP BETWEEN UVEITIS, DIFFERENT TYPES OF VIRAL HEPATITIS, AND LIVER CIRRHOSIS: A 12-Year Nationwide Population-Based Cohort Study
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Peng-Tai Tien1, Chun-Ju Lin, Yi-Yu Tsai
1*Graduate Institute of Clinical Medical Science, College of Medicine, China Medical University, Taichung, Taiwan;†Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan;‡School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan;§An-Shin Dialysis Center, NephroCare Ltd, Fresenius Medical Care, Taichung, Taiwan;¶Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan;**Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan;††College of Medicine, China Medical University, Taichung, Taiwan; and‡‡School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung, Taiwan.
Purpose:
This study investigates whether patients with viral hepatitis and cirrhosis are at risk of uveitis in the years following hepatitis.
Methods:
We used data from Taiwan National Health Insurance system. The cases were patients newly diagnosed with viral hepatitis from 2000 to 2011. The end point of interest was a diagnosis of uveitis. A chi-square test was used for the difference of demographic characteristics between viral hepatitis and comparison. The risk of uveitis in hepatitis was stratified using Cox proportional hazard regression.
Results:
We selected 17,389 patients with viral hepatitis and 34,778 matched comparison. The risk of uveitis in hepatitis cohort was 1.30-fold (95% confidence interval = 1.01-1.69). Patients with hepatitis B virus and hepatitis C virus coinfection had the highest risk (hazard ratio = 2.88; 95% confidence interval = 1.07-7.78), and followed by only hepatitis C virus infection (hazard ratio = 1.75; 95% confidence interval = 1.10-2.79). Patients with cirrhosis had a higher risk in the multivariable model but did not attach statistic difference.
Conclusion:
Patients with hepatitis B virus and hepatitis C virus coinfection had the highest risk of uveitis. In patients with hepatitis C virus and/or hepatitis B virus infection, the symptoms of uveitis should be alerted. Although these epidemiologic studies yielded informative results, the underlying mechanisms and the host's genetic factors remain to be investigated.
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