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The Association between Premature Adrenarche and Cardiovascular Risk May Be Greater than Expected

Nurullah Çelik1, Hayrullah Alp, Emine Çamtosun

  • 1Department of Pediatric Endocrinology, Malatya Beydağı State Hospital, Malatya, Turkey.

Hormone Research in Paediatrics
|November 22, 2016
PubMed

Insights

Children with premature adrenarche (PA) show early signs of cardiovascular disease, including atherosclerosis and impaired heart function. These findings suggest a heightened risk for developing cardiovascular issues later in life.

Area of Science:

  • Pediatric Endocrinology
  • Cardiovascular Medicine
  • Metabolic Disorders

Background:

  • Premature adrenarche (PA) is associated with early puberty and potential metabolic disturbances.
  • Understanding the long-term cardiovascular implications of PA in children is crucial for early intervention.

Purpose of the Study:

  • To investigate the cardiovascular risk profile in children diagnosed with premature adrenarche.
  • To compare metabolic, anthropometric, and echocardiographic parameters between children with PA and healthy controls.

Main Methods:

  • A cohort of 75 children (44 with PA, 31 controls), aged 6-10 years, was studied.
  • Key metabolic markers (triglycerides, DHEA-SO4, 17-hydroxyprogesterone) were measured.
  • Echocardiographic assessments, carotid intima-media thickness, and epicardial adipose tissue were evaluated.

Main Results:

  • Children with PA exhibited elevated triglyceride, DHEA-SO4, and 17-hydroxyprogesterone levels.
  • Significant echocardiographic differences included increased LVEDD, altered LV/RV ejection times, and elevated LV/RV Tei indices in the PA group.
  • Increased carotid intima-media thickness and epicardial adipose tissue were observed in children with PA.

Conclusions:

  • Children with premature adrenarche display early atherosclerotic changes.
  • Subclinical impairment of cardiac function is evident in this pediatric population.
  • PA may indicate an increased predisposition to early-onset cardiovascular disease.
Abstract

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