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Hepatoprotective triterpenoids and lignans from the stems of Schisandra pubescens
Guo-Wei Wang1, Li-Qing Deng1, You-Ping Luo1
1a College of Pharmaceutical Sciences, Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education , Southwest University , Chongqing , P.R. China.
Abstract:
One new triterpenoid (1) and 13 known compounds (2-14) were isolated from Schisandra pubescens stems. The structure of the new compound was established on the basis of 1D/2D NMR and HRESIMS spectroscopic analyses. The isolated compounds were evaluated for their hepatoprotective activities against D-GalN-induced cell injury in QSG7701 cells. Compounds 1, 13 and 14 at 10 μM showed hepatoprotective activities, with survival rates of 60.5, 50.4 and 48.9%, respectively.

