Related Experiment Video

Updated: Mar 11, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.1K

Patients with HFpEF and HFrEF have different clinical characteristics but similar prognosis: a retrospective cohort

Tamrat Befekadu Abebe1, Eyob Alemayehu Gebreyohannes2, Yonas Getaye Tefera2

  • 1Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia. Befekadutamrat@gmail.com.

BMC Cardiovascular Disorders
|November 23, 2016
PubMed

Insights

Heart failure in Ethiopia shows distinct clinical profiles for preserved (HFpEF) and reduced (HFrEF) ejection fraction. Survival outcomes were similar between HFpEF and HFrEF, but advanced age and certain lab values predicted mortality.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • Heart failure (HF) is a significant global cardiovascular disorder with substantial morbidity and mortality.
  • In Sub-Saharan Africa, HF is a leading cardiovascular disease with considerable socioeconomic impact.
  • Ethiopian HF patients exhibit variations in clinical characteristics and survival between HF with preserved ejection fraction (HFpEF) and HF with reduced ejection fraction (HFrEF).

Purpose of the Study:

  • To characterize clinical profiles and medication use in Ethiopian patients with HFpEF and HFrEF.
  • To assess survival status and identify prognostic factors for mortality in these patient groups.
  • To compare outcomes between HFpEF and HFrEF in the Ethiopian context.

Main Methods:

  • A retrospective cohort study analyzed medical records of 311 HF patients admitted between 2010 and 2015.
  • Kaplan Meier curves and log rank tests were used to compare survival between HFpEF and HFrEF groups.
  • Cox regression analysis identified independent predictors of mortality.

Main Results:

  • The majority of patients had HFpEF (52.73%), predominantly women, with valvular and hypertensive heart disease etiologies.
  • HFrEF patients had ischemic heart disease and dilated cardiomyopathy etiologies, with higher use of ACEI and beta-blockers.
  • No statistically significant difference in mortality was observed between HFpEF and HFrEF (p=0.807).
  • Advanced age, lower sodium, higher creatinine, and absence of ACEI, spironolactone, and statins independently predicted mortality.

Conclusions:

  • Ethiopian HF patients display diverse clinical characteristics based on ejection fraction status.
  • Survival outcomes did not differ significantly between HFpEF and HFrEF patients in this cohort.
  • Prognostic factors for mortality include advanced age, specific laboratory values, and medication use.
Abstract

Keywords:
Clinical characteristicsEjection fractionEthiopiaHeart failureSurvival

More Related Videos

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.5K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.1K

Related Concept Videos

Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.3K
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
759
Heart Failure I: Introduction01:27

Heart Failure I: Introduction

Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.1K
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
510
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
455
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.2K