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Open trial of fluoxetine in obsessive-compulsive disorder
M A Jenike1, L Buttolph, L Baer
1Harvard Medical School, OCD Clinic and Research Unit, Massachusetts General Hospital, Boston 02114.
The American Journal of Psychiatry
|July 1, 1989
Abstract:
A 12-week open trial of fluoxetine in 61 obsessive-compulsive disorder patients significantly improved depressive and obsessive-compulsive symptoms. Baseline depression scores were not related to improvement on two obsessive-compulsive scales. The results reinforce the hypothesis of serotonergic abnormalities in obsessive-compulsive disorder.