Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Next-generation Sequencing

Next-generation Sequencing

The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Expression of Immune Checkpoint-Associated Proteins for CD24, Siglec-10, CD47, and SIRPα in Breast Phyllodes Tumor.

International journal of molecular sciences·2026

Same author

HER2-low and ultralow breast cancer: interobserver challenges and lessons from a consensus study.

Journal of pathology and translational medicine·2026

Same author

PR inhibition stimulates G6PD expression to enhance malignancy in luminal breast cancer.

Cell death & disease·2025

Same author

Preoperative Predictors of Subsequent Breast Cancer Events Detected on Abbreviated MRI in Patients with Early-Stage Breast Cancer.

Diagnostics (Basel, Switzerland)·2025

Same author

Impact of treatment response to neoadjuvant chemotherapy on brain metastasis patterns and breast cancer prognosis.

Breast (Edinburgh, Scotland)·2025

Same author

Characterization of pleural metastasis in non-small cell carcinomas undergoing intraoperative frozen section examination.

Journal of thoracic disease·2025

Search research articles

Related Experiment Video

Updated: Mar 11, 2026

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

Next-generation sequencing in thyroid cancer.

Yoon Jin Cha¹, Ja Seung Koo²

¹Department of Pathology, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.

Journal of Translational Medicine

|November 23, 2016

Summary

Next-generation sequencing (NGS) improves thyroid cancer diagnosis and patient risk stratification. This technology aids in molecular classification and predicting recurrence, advancing both clinical care and cancer research.

Keywords:

Cancer Cytology Next-generation sequencing Thyroid

More Related Videos

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

Related Experiment Videos

Last Updated: Mar 11, 2026

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors

Published on: September 20, 2016

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Detection of Rare Mutations in CtDNA Using Next Generation Sequencing

Published on: August 24, 2017

Area of Science:

Oncology
Genomics
Molecular Biology

Background:

Next-generation sequencing (NGS) enables high-throughput analysis of genetic alterations in thyroid cancer.
Understanding tumor biology is crucial for improving diagnosis and patient management.

Purpose of the Study:

To review the applications of NGS in thyroid cancer diagnosis and research.
To highlight the clinical and research implications of NGS for thyroid cancer.

Main Methods:

Review of previous studies utilizing NGS in various thyroid cancer sample types.
Analysis of data from fine needle aspiration (FNA) cytology, fresh frozen tissue, and formalin-fixed, paraffin-embedded tissues.

Main Results:

NGS enhances diagnostic accuracy for indeterminate FNA cytology findings.
NGS facilitates risk stratification, molecular tumor classification, and prediction of recurrence and metastasis in papillary thyroid carcinoma.

Conclusions:

NGS is a valuable tool for advancing thyroid cancer diagnosis, patient management, and research.
The comprehensive genetic insights from NGS are transforming the study and treatment of thyroid cancer.