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Is Testosterone a Food for the Brain?

Giacomo Ciocca1, Erika Limoncin1, Eleonora Carosa1

  • 1Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy.

Sexual Medicine Reviews
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PubMed
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Low testosterone levels negatively impact mental health, sexual function, and cognition in both men and women. Assessing testosterone is crucial for managing various health conditions and improving overall quality of life.

Keywords:
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Area of Science:

  • Neuroendocrinology
  • Psychoneuroendocrinology
  • Reproductive Endocrinology

Background:

  • Testosterone is vital for psychological, sexological, cognitive, and reproductive functions.
  • Reduced testosterone levels significantly diminish quality of life in both males and females.

Purpose of the Study:

  • To review the role of testosterone in brain neurophysiology.
  • To examine testosterone's impact on general and sexual quality of life.

Main Methods:

  • Literature review of studies from January 2000 to June 2015.
  • Searches conducted in PubMed using specific keywords.
  • Analysis focused on psychoneuroendocrinology, including brain, sexuality, psychopathology, and cognition.

Main Results:

  • Testosterone influences brain activity, sexual function, psychological health, and aging.
  • Testosterone deficiency negatively affects quality of life, primarily through central mechanisms.
  • Differential expression of testosterone and androgen receptors contributes to gender-specific roles.

Conclusions:

  • Low testosterone is universally linked to mental disorders, sexual dysfunction, and cognitive impairment in both sexes.
  • Physicians should evaluate testosterone levels in patients with sexual dysfunction, mental health issues, or organic diseases.