Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endophenotypes, Epigenetics, Polygenicity and More: Irv Gottesman's Dynamic Legacy.

David L Braff1, Carol A Tamminga2

  • 1Department of Psychiatry, University of California, San Diego, La Jolla, CA; dbraff@ucsd.edu.

Schizophrenia Bulletin
|November 23, 2016
PubMed
Summary

Irv Gottesman

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Associations of social and genetic background variables to neuro-cognitive biomarkers of psychosis.

Biomarkers in neuropsychiatry·2026
Same author

Family-Level Brain Pattern Similarities and Their Clinical Significance in Young Offspring of Individuals With Psychotic Disorders.

Biological psychiatry. Cognitive neuroscience and neuroimaging·2026
Same author

Confirmatory efficacy and safety trial of magnetic seizure therapy versus right unilateral ultra-brief electroconvulsive therapy in depression (CREST-MST): a randomised, double-blind, non-inferiority trial in Canada and the USA.

The lancet. Psychiatry·2026
Same author

Neuroanatomical Deficits in Visual Cortex Subregions of Individuals With Psychosis Spectrum Disorders Linked to Symptoms, Cognition, and Childhood Trauma.

Schizophrenia bulletin·2026
Same author

Signatures of altered free-water and cognition and associations with symptom severity in psychosis spectrum disorders.

Brain, behavior, and immunity·2026
Same author

Biological insights into schizophrenia from ancestrally diverse populations.

Nature·2026

Area of Science:

  • Psychiatric Genetics
  • Neuroscience
  • Schizophrenia Research

Background:

  • Reviews Gottesman's foundational contributions to schizophrenia research, including polygenicity, gene-environment interactions, epigenetics, and the endophenotype concept.
  • Highlights Gottesman's twin studies demonstrating the genetic mediation of schizophrenia risk over social factors.
  • Introduces the endophenotype concept as a quantitative, biologically-based measure for understanding schizophrenia's genetic architecture.

Discussion:

  • Examines the Consortium on the Genetics of Schizophrenia (COGS) and its investigation of neurocognitive and neurophysiological endophenotypes.
  • Discusses the Bipolar and Schizophrenia Network for Intermediate Phenotypes (BSNIP) and its use of diverse endophenotypes, including brain imaging, across the psychosis spectrum.
  • Illustrates how these consortia leverage endophenotypes for gene discovery and understanding the genetic basis of psychosis.
Keywords:
Gottesmanbiomarkersendophenotypesgenesschizophrenia

Related Experiment Videos

Key Insights:

  • Schizophrenia risk is significantly influenced by genetic factors, as evidenced by Gottesman's twin studies.
  • Endophenotypes provide a more direct link to underlying genetic mechanisms than traditional diagnostic categories.
  • Consortia like COGS and BSNIP are advancing schizophrenia research through large-scale endophenotype studies.

Outlook:

  • Endophenotypes offer a promising avenue for identifying specific genes, neural circuits, and treatment targets for schizophrenia.
  • The concept of biotypes, emerging from BSNIP, represents a significant advancement in dimensional analysis of psychosis.
  • Gottesman's conceptual framework continues to guide contemporary schizophrenia research, predicting key challenges and research directions.