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Diagnostic Utility of ANG in Coronary Heart Disease Complicating Chronic Heart Failure: A Cross-Sectional Study

Peng Yu1, Ming Liu1, Xue Yang1

  • 1Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Shanghai Medical College of Fudan University, Shanghai 200032, China.

Disease Markers
|November 23, 2016
PubMed

Insights

Plasma Angiogenin (ANG) is elevated in patients with coronary heart disease (CHD) complicated by chronic heart failure (CHF). ANG may serve as a diagnostic marker for identifying CHF in CHD patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Heart Failure

Background:

  • Angiogenin (ANG) is implicated in cardiovascular diseases.
  • Elevated ANG levels are observed in various heart conditions.
  • The role of ANG in coronary heart disease (CHD) with complicating chronic heart failure (CHF) requires further investigation.

Purpose of the Study:

  • To determine plasma ANG levels in CHD patients with and without CHF.
  • To evaluate the diagnostic capacity of ANG for CHF in CHD patients.
  • To compare ANG levels between different heart failure subtypes (HFrEF vs. HFpEF).

Main Methods:

  • A cross-sectional study involving 616 CHD patients and 53 healthy controls.
  • Patients were categorized into CHF group, CHD disease controls, and healthy controls.
  • Plasma ANG levels were measured using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • Plasma ANG levels were significantly higher in the CHF group (342.8 ng/mL) compared to CHD controls (304.5 ng/mL) and healthy controls (279.7 ng/mL).
  • Within the CHF group, ANG levels were markedly higher in heart failure with reduced ejection fraction (HFrEF) patients than in heart failure with preserved ejection fraction (HFpEF) patients.
  • The area under the receiver operating characteristic curve for ANG was 0.71, indicating moderate diagnostic capacity.

Conclusions:

  • Plasma ANG is elevated in patients with CHD complicating CHF.
  • ANG demonstrates potential as a moderate discriminator for identifying CHF in CHD patients.
  • Further research may elucidate ANG's specific role in heart failure pathophysiology.

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