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Antigen-Presenting Cells and Antigen Presentation in Tertiary Lymphoid Organs

Catherine E Hughes1, Robert A Benson1, Marija Bedaj2

  • 1Centre for Immunobiology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow , Glasgow , UK.

Frontiers in Immunology
|November 23, 2016
PubMed

Tertiary lymphoid organs (TLOs) form in territorialized niches of peripheral tissues characterized by the presence of antigens; however, little is known about mechanism(s) of antigen handling by ectopic lymphoid structures. In this mini review, we will discuss the role of antigen-presenting cells and mechanisms of antigen presentation in TLOs, summarizing what is currently known about this facet of the formation and function of these tissues as well as identifying questions yet to be addressed.

Keywords:
B cellsantigen presentationantigen-presenting cellsdendritic cellsfollicular dendritic cellsmacrophagestertiary lymphoid organs

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