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Array Biosensor for Toxin Detection: Continued Advances.

Chris Rowe Taitt¹, Lisa C Shriver-Lake², Miriam M Ngundi³

¹Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, Code 6900, Washington, DC 20375-5348, USA. chris.taitt@nrl.navy.mil.

Sensors (Basel, Switzerland)

|November 23, 2016

Summary

The NRL Array Biosensor offers rapid, simultaneous detection of multiple targets. Recent advancements have automated and miniaturized this portable system for point-of-use applications, enhancing its reliability.

Keywords:

biosensor clinical diagnostics detection food multi-analyte multiplex toxin

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Area of Science:

Biomedical Engineering
Analytical Chemistry
Biosensing Technology

Background:

The NRL Array Biosensor, developed for rapid, simultaneous detection of multiple targets, has undergone significant advancements.
Previous iterations required manual operation, limiting its application at the point-of-use.

Approach:

Review of progress in the last five years focusing on automation and miniaturization of the NRL Array Biosensor.
Demonstration of quantitative immunoassays for toxins and indicators in diverse matrices.
Evaluation of semi-selective molecules as alternative recognition elements.

Key Points:

The Array Biosensor is now automated and miniaturized for point-of-use operation.
Quantitative immunoassays have been successfully developed for an expanded range of toxins and indicators.
Semi-selective molecules show promise as effective recognition moieties.

Conclusions:

The automated NRL Array Biosensor system is versatile, sensitive, and reliable for detecting multiple targets.
Blind trials in various matrices confirm the system's performance in real-world scenarios.
The advancements enable broader applications in food safety and clinical diagnostics.