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Are familial abdominal aortic aneurysms different?

R C Darling1, D C Brewster, R C Darling

  • 1General Surgical Services, Massachusetts General Hospital, Boston 02114.

Journal of Vascular Surgery
|July 1, 1989
PubMed
Summary

Familial abdominal aortic aneurysms are more common than previously thought, affecting 15.1% of patients. This genetic link highlights the importance of family history in screening for abdominal aortic aneurysms.

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Area of Science:

  • Vascular Surgery
  • Genetics
  • Epidemiology

Background:

  • Abdominal aortic aneurysms (AAAs) represent a significant vascular disease.
  • The familial aggregation of AAAs suggests a genetic predisposition.
  • Understanding familial AAA characteristics is crucial for risk stratification.

Purpose of the Study:

  • To determine the incidence of familial abdominal aortic aneurysms.
  • To define the clinical behavior and anatomic features of familial AAAs.
  • To compare familial AAA patients with non-familial AAA patients.

Main Methods:

  • Prospective study of 542 AAA patients over 9 years.
  • Analysis of pedigree charts for 86 families with familial AAAs.
  • Comparison of clinical and anatomic data between familial (n=209) and non-familial (n=460) AAA patients.

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Main Results:

  • Familial AAA incidence was 15.1% in surgical patients, significantly higher than controls (1.8%).
  • Familial AAA patients were more likely to be women (35% vs 14%).
  • Aneurysm rupture occurred in 40.7% of familial AAA families.

Conclusions:

  • A significant proportion of abdominal aortic aneurysms have a familial component.
  • Familial AAA presentation differs, with a higher prevalence in women.
  • Family history is a critical factor in identifying individuals at risk for abdominal aortic aneurysms.