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Updated: Mar 11, 2026

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[Antibiotics and gait disorders].

P Gomez-Porro1, A Vinagre-Aragon1, J A Zabala-Goiburu1

  • 1Hospital Universitario Puerta de Hierro-Majadahonda, 28035 Majadahonda, Espana.

Revista De Neurologia
|November 23, 2016
PubMed
Summary

Antibiotics can cause neurological toxicity, leading to gait disorders. This review classifies antibiotics by their mechanism of action, aiding in clinical diagnosis and patient management.

Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Medicine

Background:

  • Neurological toxicity is a known side effect of many antibiotics.
  • Gait disturbances are a significant manifestation of this toxicity.
  • Existing literature lacks a systematic classification of antibiotics based on gait disorder mechanisms.

Purpose of the Study:

  • To classify antibiotics based on their physiopathogenic mechanisms causing gait disorders.
  • To consolidate clinical and experimental data on antibiotic-induced gait disturbances.
  • To aid clinicians in identifying and managing patients with antibiotic-related gait issues.

Main Methods:

  • Conducted an exhaustive literature search on Google Scholar and PubMed.
  • Included reviews, articles, and clinical cases on antibiotic-induced gait disorders.

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  • Classified antibiotics by their physiopathogenic mechanisms (cerebellar, vestibular, sensitive ataxia, extrapyramidal).

    • Main Results:

    • Identified and categorized antibiotics associated with various types of ataxia and extrapyramidal gait disorders.
    • Detailed the physiopathogenic mechanisms linking specific antibiotics to gait disturbances.
    • Provided a comprehensive overview of drugs implicated in neurological gait abnormalities.

    Conclusions:

    • Antibiotic-induced gait disorders can be systematically classified by underlying mechanisms.
    • This classification facilitates clinical suspicion and diagnosis.
    • Improved understanding aids in timely and effective patient management.