Coarctation repair normalizes left ventricular function and aorto-septal angle in neonates
Haki Jashari1, Katarina Lannering2, Mats Mellander2
1Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Congenital Heart Disease
|November 23, 2016
Summary
Coarctation of the aorta (CoA) causes a wider aorto-septal angle (AoSA) and impacts left ventricular (LV) function. Surgical repair normalizes AoSA and improves LV function and deformation.
Area of Science:
- Pediatric Cardiology
- Cardiac Imaging
- Congenital Heart Disease
Background:
- Coarctation of the aorta (CoA) increases left ventricular (LV) afterload, affecting LV and ascending aortic function.
- The aorto-septal angle (AoSA) is a potential indicator of these hemodynamic changes.
Purpose of the Study:
- To investigate the effect of CoA on LV function and AoSA before and after surgical repair.
- To correlate AoSA with LV function and deformation parameters.
Main Methods:
- Retrospective study of 21 patients with surgically repaired CoA.
- AoSA measurement at three cardiac cycle time points before and after intervention.
- Assessment of LV structure, function, global longitudinal strain, and strain rate using STE.
Main Results:
- AoSA was significantly wider in neonates with CoA, particularly at peak ejection, correlating with CoA pressure gradient.
- Post-intervention, AoSA normalized and correlated with improved LV cavity function and global deformation.
Conclusions:
- Abnormally wide AoSA in neonates with CoA is linked to obstruction severity, LV dysfunction, and impaired LV global deformation.
- AoSA normalization after repair indicates improved LV mechanics.
