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Epicardial fat thickness is associated with severity of disease in patients with chronic obstructive pulmonary

K Kiraz1, T Gökdeniz, E Kalaycıoglu

  • 1Department of Chest Disease, Antalya Atatürk State Hospital, Antalya, Turkey. drkemalkiraz@gmail.com.

European Review for Medical and Pharmacological Sciences
|November 23, 2016
PubMed

Insights

Epicardial fat thickness (EFT) is linked to disease severity in chronic obstructive pulmonary disease (COPD) patients. Higher EFT correlates with better prognosis, suggesting EFT as a potential marker for COPD progression.

Area of Science:

  • Cardiology
  • Pulmonology
  • Medical Imaging

Background:

  • Cardiovascular diseases (CVD) are prevalent in patients with chronic obstructive pulmonary disease (COPD).
  • Epicardial fat thickness (EFT) is a known indicator of cardiovascular risk.
  • The BODE index is crucial for assessing COPD prognosis, but its relationship with EFT is underexplored.

Purpose of the Study:

  • To investigate the association between epicardial fat thickness (EFT) and the BODE index in patients diagnosed with COPD.

Main Methods:

  • A prospective study included 157 COPD patients and 45 controls.
  • Echocardiography measured EFT; pulmonary function and exercise capacity were assessed.
  • Patients were stratified into BODE index quartiles (Q1-Q4).

Main Results:

  • COPD patients exhibited significantly higher EFT than controls.
  • EFT values were highest in the lowest BODE index quartile (Q1) and decreased across quartiles.
  • Multivariate analysis revealed EFT was independently associated with BODE index, Hs-CRP, and diabetes.

Conclusions:

  • Epicardial fat thickness (EFT) is negatively associated with COPD severity, as indicated by the BODE index.
  • EFT may serve as a potential biomarker for disease severity and cardiovascular risk in COPD patients.
Abstract

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