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Updated: Mar 11, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Evaluation of a new solid non-aqueous self-double-emulsifying drug-delivery system for topical application of
Qiang Wang1,2, Caibiao Hu1,2, Hong Zhang1,2
1a School of Biological Science and Medical Engineering, State Key Laboratory of Bioelectronics , Southeast University , Nanjing , China.
Abstract:
This study aimed to the evaluation of a new solid non-aqueous self-double-emulsifying drug-delivery system (SDEDDS) for topical application of quercetin. The new formulation was prepared through two-step emulsification process and could spontaneously form oil-in-oil-in-water (O/O/W) double emulsions after dilution with aqueous medium, with inner oil phase mainly containing the drug. Solid state characterisation was performed by DSC and X-ray powder diffraction. Furthermore, the optimised QT-SDEDDS displayed sustained release profile and was found to be stable up to 30 days under 4 °C and 25 °C. Antioxidant capacities showed that quercetin could be protected by the solid non-aqueous SDEDDS. Compared with the quercetin ethanol aqueous solution, the QT-SDEDDS exhibited higher permeation ability, and significantly increased accumulation of quercetin in the skin. These studies demonstrated that the solid non-aqueous SDEDDS might be a promising carrier for topical application of poorly water-soluble and simultaneously poorly oil-soluble drugs, such as quercetin.
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