Related Experiment Video
Updated: Mar 11, 2026
Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
Published on: April 11, 2018
EMG-Driven Optimal Estimation of Subject-SPECIFIC Hill Model Muscle-Tendon Parameters of the Knee Joint Actuators
Objective:
the purpose of this paper is to propose an optimal control problem formulation to estimate subject-specific Hill model muscle-tendon (MT-) parameters of the knee joint actuators by optimizing the fit between experimental and model-based knee moments. Additionally, this paper aims at determining which sets of functional motions contain the necessary information to identify the MT-parameters.
Methods:
the optimal control and parameter estimation problem underlying the MT-parameter estimation is solved for subject-specific MT-parameters via direct collocation using an electromyography-driven musculoskeletal model. The sets of motions containing sufficient information to identify the MT-parameters are determined by evaluating knee moments simulated based on subject-specific MT-parameters against experimental moments.
Results:
the MT-parameter estimation problem was solved in about 30 CPU minutes. MT-parameters could be identified from only seven of the 62 investigated sets of motions, underlining the importance of the experimental protocol. Using subject-specific MT-parameters instead of more common linearly scaled MT-parameters improved the fit between inverse dynamics moments and simulated moments by about 30% in terms of the coefficient of determination (from [Formula: see text] to [Formula: see text]) and by about 26% in terms of the root mean square error (from [Formula: see text] to [Formula: see text] ). In particular, subject-specific MT-parameters of the knee flexors were very different from linearly scaled MT-parameters.
Conclusion:
we introduced a computationally efficient optimal control problem formulation and provided guidelines for designing an experimental protocol to estimate subject-specific MT-parameters improving the accuracy of motion simulations.
Significance:
the proposed formulation opens new perspectives for subject-specific musculoskeletal modeling, which might be beneficial for simulating and understanding pathological motions.
