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The impact of transposable elements on mammalian development

Jose L Garcia-Perez1,2, Thomas J Widmann2, Ian R Adams1

  • 1Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK jose.garcia-perez@igmm.ed.ac.uk ian.adams@igmm.ed.ac.uk.

Development (Cambridge, England)
|November 23, 2016
PubMed
Summary

Transposable elements (TEs), once called junk DNA, significantly impact mammalian development and gene regulation. Their activity generates genetic variation and provides regulatory elements, fueling mammalian evolution.

Keywords:
Endogenous retrovirusGenetic variationGenome regulationLINE-1Retrotransposon

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