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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
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Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
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Cutaneous malignancies in HIV.

Aileen Y Chang1, Phil Doiron, Toby Maurer

  • 1aDepartment of Dermatology, University of California, San Francisco, San Francisco, California, USA bDepartment of Dermatology, University of Toronto, Toronto, Ontario, Canada cDepartment of Dermatology, Zuckerberg San Francisco General Hospital, San Francisco, California, USA.

Current Opinion in HIV and AIDS
|November 23, 2016
PubMed
Summary
This summary is machine-generated.

Skin cancer, particularly squamous cell carcinoma, is an increasing concern for the aging human immunodeficiency virus (HIV) population. This review highlights the scope of skin cancer in HIV domestically and internationally.

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Area of Science:

  • Oncology
  • Dermatology
  • Infectious Diseases

Background:

  • Human immunodeficiency virus (HIV) infection is increasingly a chronic condition, leading to an aging patient population.
  • The evolution of comorbidities, including skin cancer, is observed in long-term HIV survivors.
  • Limited data exists from cancer registries on the incidence and prevalence of skin cancers in HIV-infected individuals.

Purpose of the Study:

  • To elucidate the extent of skin cancer as a significant health issue in the HIV-infected population, both domestically and internationally.
  • To inform clinicians about risk factors for skin cancer in the aging HIV population.
  • To provide insights into prevention and treatment strategies for skin cancer in the context of modern HIV management.

Main Methods:

  • Review of relevant cohort data and literature on skin cancer incidence in HIV-infected individuals.
  • Contrast of squamous cell carcinoma with other skin cancers like melanoma and basal cell carcinoma.
  • Analysis of demographic, host, and environmental factors influencing skin cancer presentation.

Main Results:

  • Squamous cell carcinoma incidence is rising globally, including in the United States.
  • Anatomic distribution of skin cancers varies based on patient demographics, host factors, and environmental exposures.
  • The aging HIV population presents unique challenges and considerations for skin cancer development.

Conclusions:

  • Clinicians must be aware of the increasing risk of skin cancer in aging patients with HIV.
  • Understanding risk factors is crucial for early detection and prevention strategies.
  • Further research and informed clinical practice are needed to address the growing burden of skin cancer in HIV.