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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genetic Screens02:46

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Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
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Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
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Evolutionary Relationships through Genome Comparisons02:54

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Next-generation Sequencing03:00

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
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CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Updated: Mar 11, 2026

Novel Sequence Discovery by Subtractive Genomics
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Skepticism in the Genomic Era.

Rachel L Zacharias

    The Hastings Center Report
    |November 23, 2016
    PubMed
    Summary

    Neuroscience and genomics research explores gene, epigenetic, and environmental interactions influencing behavior. Critiques of "genomic hype" contrast with optimistic initiatives like the Human Genome Project.

    Area of Science:

    • Neuroscience and Genomics
    • Bioethics and Law

    Background:

    • Research in neuroscience and genomics investigates the complex interplay of genetic, epigenetic, and environmental factors.
    • This field examines how these factors influence neuronal activity and behavior, impacting legal, ethical, and policy considerations.

    Purpose of the Study:

    • To explore the tension between scientific optimism in genomics and critiques of "genomic hype."
    • To analyze the implications of advancements in neuroscience and genomics for law, ethics, and policy.

    Main Methods:

    • Literature review of "genomic hype" critiques.
    • Analysis of rhetoric from the Human Genome Project and Precision Medicine Initiative.

    Main Results:

    • Identified a significant divergence between optimistic projections in major genomic initiatives and critical assessments in recent literature.

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  • Highlighted the need for nuanced understanding of gene-environment interactions in behavioral research.

    • Conclusions:

    • Reconciling the promise of genomic advancements with realistic expectations is crucial for responsible scientific and policy development.
    • Further research is needed to bridge the gap between hype and the actualizable potential of genomic and neuroscience discoveries.