Emerging roles and mechanisms of long noncoding RNAs in atherosclerosis

Atherosclerosis is the most common cause of heart attacks, strokes, and peripheral vascular disease. Atherosclerosis is predicted to be the primary cause of death in the world by 2020. Increasing evidence suggests that long non-protein-coding RNAs (lncRNAs) are important for the regulation of tissue homeostasis and pathophysiological conditions. Although knowledge about lncRNAs in atherosclerosis and other cardiovascular diseases is sparse, lncRNAs are clinically interesting because of their diagnostic and therapeutic value. This review summarizes knowledge about lncRNAs through their actions, related research methods and effects on atherosclerosis to provide helpful insights about how lncRNAs work and control atherosclerosis process and how lncRNA-related strategies could benefit human beings.