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Updated: Mar 11, 2026

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Beyond the lymph nodes: FDG-PET/CT in primary extranodal lymphoma
Kin Man Sin1, Stanton King Dat Ho1, Brian Yung Kong Wong1
1Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong.
Abstract:
Extranodal lymphoma can be the primary presentation or secondary to systemic involvement of lymphoma. 2-(fluorine-18) fluoro-2-deoxy-d-glucose positron emission tomography with computer tomography (FDG-PET/CT) is useful in detecting extranodal sites during staging, treatment response assessment or recurrence detection in patients with lymphoma. In this article, we reviewed the imaging features and FDG avidity of primary extranodal lymphoma of various organs and systems on FDG-PET/CT, demonstrating the pearls and pitfalls of FDG-PET/CT in evaluating this disease entity and cross-referencing to other imaging modalities that aid in diagnosis and management.
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