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Published on: February 26, 2013
Association of Preoperative Platelet-to-Lymphocyte Ratio with Atrial Fibrillation after Coronary Artery Bypass Graft
Hasan Gungor1, Abraham Samuel Babu, Cemil Zencir
1Department of Cardiology, Adnan Menderes University, Aydin, Turkey.
Insights
Elevated preoperative platelet-to-lymphocyte ratio (PLR) is linked to a higher risk of atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery. Age and PLR are independent predictors of post-CABG AF.
Area of Science:
- Cardiology
- Oncology
- Inflammation Research
Background:
- Atrial fibrillation (AF) is a common complication following coronary artery bypass graft (CABG) surgery.
- Identifying predictive markers for post-CABG AF is crucial for patient management.
- The platelet-to-lymphocyte ratio (PLR) is an emerging inflammatory marker.
Purpose of the Study:
- To investigate the association between preoperative platelet-to-lymphocyte ratio (PLR) and the incidence of AF after CABG surgery.
- To determine if PLR is an independent predictor of post-CABG AF.
- To evaluate the diagnostic performance of PLR in predicting post-CABG AF.
Main Methods:
- Retrospective analysis of 125 patients undergoing CABG surgery.
- Calculation of preoperative PLR from blood samples.
- Statistical analysis including univariate, multivariate logistic regression, and ROC curve analysis to assess the association and predictive value of PLR for AF.
Main Results:
- A significantly higher PLR was observed in patients who developed AF post-CABG compared to those who did not (152.8 ± 82.2 vs. 118.2 ± 32.9, p = 0.012).
- Both age and PLR were identified as independent predictors of post-CABG AF in multivariate analysis (p < 0.001 and p = 0.005, respectively).
- A PLR cutoff value of >119.3 demonstrated 64% sensitivity and 56% specificity for predicting postoperative AF (AUC: 0.634, p = 0.012).
Conclusions:
- Preoperative PLR is an independent predictor of atrial fibrillation after CABG surgery.
- Elevated preoperative PLR levels are associated with an increased risk of developing AF post-CABG.
- PLR may serve as a valuable biomarker for risk stratification in patients undergoing CABG.
Objective:
The aim of this study was to investigate the association between platelet-to-lymphocyte ratio (PLR) and atrial fibrillation (AF) after coronary artery bypass graft (CABG) surgery.
Subjects And Methods:
A total of 125 patients were retrospectively analyzed. AF was diagnosed using standard clinical criteria, and PLR was calculated as the ratio of the platelets to lymphocytes, obtained from the blood samples that were taken in the fasting state before CABG surgery. The association of different variables with postoperative AF and PLR was calculated using univariate and multivariate analysis. The receiver operating characteristics curve was used to determine the sensitivity and specificity of PLR and the optimal cutoff value for predicting post-CABG AF.
Results:
Of the 125 patients, 50 with AF (mean age: 67.0 ± 9.5 years, 38 males and 12 females) and 75 patients without AF (mean age: 61.1 ± 9.1 years, 58 males and 17 females) were identified, and the difference in the mean age was statistically significant (p = 0.01). PLR was also significantly higher in those with AF (152.8 ± 82.2) than those without AF (118.2 ± 32.9) (p = 0.012). Univariate analysis showed that age and PLR were associated with AF after CABG surgery (p < 0.001 and p = 0.005, respectively). Using a multivariate logistic regression model with the backward elimination method, age and PLR remained as independent predictors of AF after CABG surgery (p < 0.001 and p = 0.005, respectively). PLR levels >119.3 predicted postoperative AF with 64% sensitivity and 56% specificity (AUC: 0.634, p = 0.012).
Conclusion:
In this study, age and PLR level were independent predictors of AF after CABG surgery. Patients with an elevated preoperative PLR were at higher risk of AF after CABG surgery.
