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Biomarkers of cardiovascular injury and stress are associated with increased frequency of ventricular ectopy: a
Julia Brox Skranes1, Gunnar Einvik1, Silje Kjeka Namtvedt2
1Division of Medicine, Akershus University Hospital, Lørenskog, Norway.
Insights
Elevated N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels are independently linked to ventricular ectopy in the general population. This study found no independent association for high-sensitivity troponin I (hs-TnI) or C-reactive protein (CRP).
Area of Science:
- Cardiology
- Biomarkers
- Electrophysiology
Background:
- Asymptomatic ventricular arrhythmias increase cardiovascular mortality risk.
- Biomarkers like NT-proBNP, hs-TnI, and hs-CRP predict adverse events.
- Limited data exists on these biomarkers and ventricular ectopy in community settings.
Purpose of the Study:
- To evaluate associations between ventricular ectopic activity and NT-proBNP, hs-TnI, and hs-CRP.
- To investigate these relationships in a community-based population.
Main Methods:
- 24-hour Holter recording and blood sampling in 498 subjects.
- Ventricular ectopy defined as frequent premature ventricular complexes (>5/h) or complex arrhythmias.
- Associations analyzed using univariate and multivariate logistic regression.
Main Results:
- Frequent PVCs and complex ventricular ectopy found in 9% of participants.
- These arrhythmias were associated with significantly higher NT-proBNP and hs-TnI concentrations.
- NT-proBNP association remained significant after adjusting for risk factors.
Conclusions:
- Elevated NT-proBNP is independently associated with ventricular ectopy in a community sample.
- No independent association was found for hs-TnI or hs-CRP with ventricular ectopy.
Background:
Asymptomatic ventricular arrhythmias are common and associated with increased risk of cardiovascular mortality. Cardiac troponins, natriuretic peptides and C-reactive protein (CRP) are also predictive of adverse cardiovascular events in the general population, but limited information is available on the relationship between these biomarkers and ventricular ectopy in a community-based population. The objectives were to evaluate the associations between ventricular ectopic activity and N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity-troponin I (hs-TnI) and hs-CRP in a community-based setting.
Methods:
We performed a 24 h Holter-recording and blood sampling in 498 subjects. Premature ventricular complexes (PVC) were classified as frequent at >5/h and the presence of any bigeminy, trigeminy or non-sustained ventricular tachycardia were classified as complex ventricular ectopy. The associations between biomarkers and ventricular arrhythmias were investigated by univariate and multivariate logistic regression analyses.
Results:
Frequent PVC's and complex ventricular ectopy were detected in 46 (9%) and 47 (9%) participants respectively, and were associated with significantly (p < 0.001) higher concentrations of NT-proBNP and hs-TnI. The association between NT-proBNP and both frequent PVC's (p = 0.020) and complex ventricular ectopy (p = 0.001) remained significant after adjusting for conventional risk markers in multivariate analyses.
Conclusion:
Increased level of NT-proBNP was independently associated with ventricular ectopy, whereas no independent association was observed between hs-TnI and hs-CRP levels and ventricular ectopy in this community-based sample.
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