Associations of DNMT3B -149C>T and -2437T>A polymorphisms and lung cancer risk in Chinese population
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Updated: Mar 11, 2026

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Min Gao1, Daqiang He2, Fanji Meng3
1Department of Neurology, the Fourth Hospital of Harbin Medical University, 37 Yiyuan Street, Harbin, Heilongjiang, 150001, China. gmingao@sina.com.
Background:
DNMT3B polymorphisms are associated with the susceptibility of lung cancer. DNMT3B -2437T>A is a novel polymorphism, and its influence on the risk of lung cancer in Chinese was investigated in this study. In addition, effect of DNMT3B -149C>T polymorphism on lung cancer was also explored.
Methods:
Genotyping in subjects were performed by PCR-RFLP. Haplotype frequencies were estimated by estimating haplotype software. Adjusted odds ratios (ORs) with 95% confidence intervals (CIs) were calculated by unconditional logistic regression analysis.
Results:
Neither of the two polymorphisms was correlated with lung cancer (-149C>T: CT+TT vs CC: OR = 0.78, 95%CI, 0.57 to 1.05, P = 0.361; -2437T>A: AT+AA vs TT: OR = 0.99, 95%CI, 0.74 to 1.33, P = 0.168). In stratification analysis, T-allele carrier genotype of -149C>T polymorphism resulted in a reduced lung cancer risk at stage II, compared with CC (OR = 0.46, 95%CI, 0.28 to 0.77, P = 0.023). In haplotype analysis, when -149C/-2437T was used as reference, the other combined genotypes of the two polymorphisms had no significant effect on lung cancer risk (P > 0.05).
Conclusions:
The two DNMT3B polymorphisms are not correlated with lung cancer risk among Chinese population nor the haplotype of them.
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