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Marine sponge alkaloids as a source of anti-bacterial adjuvants
Roberta J Melander1, Hong-Bing Liu2, Matthew D Stephens1
1Department of Chemistry, North Carolina State University, Raleigh, NC 27695-8024, United States.
Abstract:
Novel approaches that do not rely upon developing microbicidal compounds are sorely needed to combat multidrug resistant (MDR) bacteria. The potential of marine secondary metabolites to serve as a source of non-traditional anti-bacterial agents is demonstrated by showing that pyrrole-imidazole alkaloids inhibit biofilm formation and suppress antibiotic resistance.
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