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Related Concept Videos

Aging01:26

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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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Related Experiment Video

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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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4-hydroxynonenal-mediated signaling and aging.

Hongqiao Zhang1, Henry Jay Forman1

  • 1Andrus Gerontology Center of the Leonard Davis School of Gerontology, University of Southern California, 3715 McClintock Ave, Los Angeles, CA 90089-0191, USA.

Free Radical Biology & Medicine
|November 24, 2016
PubMed
Summary
This summary is machine-generated.

4-Hydroxy-2-nonenal (HNE), a product of lipid peroxidation, increases with aging and influences cell signaling. This review explores how HNE contributes to age-related changes in signaling pathways.

Keywords:
4-HydroxynonealAgingHNEOxidative stressRedox signaling

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Gerontology

Background:

  • 4-Hydroxy-2-nonenal (HNE) is a major α, β-unsaturated aldehyde product of lipid peroxidation.
  • Increased HNE production is observed with aging.
  • Aging is characterized by altered cellular signaling pathway responses.

Purpose of the Study:

  • To review the role of HNE in age-related alterations of cellular signaling pathways.
  • To discuss the potential contribution of HNE to the aging process.

Main Methods:

  • Literature review of studies on lipid peroxidation, HNE, and aging.
  • Analysis of signaling pathways affected by HNE.
  • Discussion of the link between HNE and age-associated signaling changes.

Main Results:

  • HNE acts as a potent messenger in mediating signaling pathways.
  • Aging is associated with increased lipid peroxidation and HNE production.
  • Specific signaling pathways exhibit altered responses in aging, potentially influenced by HNE.

Conclusions:

  • HNE may play a significant role in mediating age-related changes in cellular signaling.
  • Understanding HNE's role is crucial for addressing age-associated signaling dysregulation.