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Increased miR-132 level is associated with visual memory dysfunction in patients with depression.

Ye Liu1, Xiao Yang1, Liansheng Zhao1

  • 1Psychiatric Laboratory, Department of Psychiatry; National Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China.

Neuropsychiatric Disease and Treatment
|November 24, 2016
PubMed
Summary

Increased microRNA-132 (miR-132) levels in unmedicated major depressive disorder (MDD) patients correlate with visual memory deficits. This suggests miR-132 may play a role in MDD pathophysiology.

Keywords:
CANTABcognitionmajor depressive disordermemorymiR-132

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Area of Science:

  • Neuroscience
  • Molecular Psychiatry
  • Biomarkers

Background:

  • Visual memory impairment is a key feature of depression.
  • Elevated microRNA-132 (miR-132) levels are frequently observed in patients with major depressive disorder (MDD).

Purpose of the Study:

  • To investigate the association between miR-132 levels and visual memory deficits in unmedicated MDD patients.
  • To explore the relationship between miR-132, visual memory, and clinical symptoms in MDD.

Main Methods:

  • Quantitative real-time polymerase chain reaction measured miR-132 expression in 62 unmedicated MDD patients and 73 healthy controls.
  • The Cambridge Neuropsychological Test Automated Battery (CANTAB) pattern recognition memory (PRM) task assessed visual memory.
  • Correlations were analyzed between miR-132 levels, visual memory performance, and clinical symptom scores.

Main Results:

  • MDD patients exhibited significantly higher miR-132 expression compared to healthy controls.
  • MDD patients showed impaired visual memory, particularly delayed recall, compared to controls.
  • Increased miR-132 levels in MDD patients were significantly correlated with poorer performance on the CANTAB PRM task.

Conclusions:

  • Elevated miR-132 expression is linked to visual memory deficits in MDD, potentially contributing to the disorder's pathophysiology.
  • Immediate visual memory deficits in depressed individuals were positively correlated with anxiety symptoms.