Systemic abnormalities of psoriatic patients: a retrospective study

Area of Science:

• Immunodermatology
• Systemic Inflammation
• Clinical Pathology

Background:

• Psoriasis is a chronic immune-mediated disease linked to metabolic and cardiovascular conditions.
• Existing research lacks focus on systemic abnormalities in psoriasis patients.
• Comorbidities highlight the need to investigate systemic effects in psoriasis.

Purpose of the Study:

• To conduct a detailed assessment of systemic abnormalities in psoriatic patients.
• To identify specific systemic indexes affected in psoriasis.
• To establish a baseline of systemic health before treatment.

Main Methods:

• Retrospective analysis of hospitalized psoriatic patients (July 2009-September 2015).
• Inclusion criteria: first-time hospitalization, no systemic therapy or phototherapy for at least 1 month.
• Evaluation of blood routine, urine, blood biochemical examinations, and chest X-rays.

Main Results:

• Psoriatic patients showed significantly higher abnormality rates in blood, urine, biochemical tests, and chest X-rays compared to controls.
• Psoriasis patients had higher absolute leukocyte and neutrophil counts, and lower lymphocyte counts.
• Erythrodermic psoriasis exhibited greater blood biochemical and electrolyte abnormalities, higher leukocytes/neutrophils, and lower serum calcium than psoriasis vulgaris.

Conclusions:

• This study provides the first detailed assessment of pre-treatment systemic abnormalities in psoriasis.
• Clinicians should monitor the systemic condition of psoriatic patients before initiating systemic therapy.
• Findings underscore the systemic impact of psoriasis and the need for comprehensive patient evaluation.