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Tau Structures
Jesus Avila1, Juan S Jiménez2, Carmen L Sayas3
1Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-UAM)Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades NeurodegenerativasMadrid, Spain.
Abstract:
Tau is a microtubule-associated protein that plays an important role in axonal stabilization, neuronal development, and neuronal polarity. In this review, we focus on the primary, secondary, tertiary, and quaternary tau structures. We describe the structure of tau from its specific residues until its conformation in dimers, oligomers, and larger polymers in physiological and pathological situations.
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