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Related Concept Videos

Introduction to Structures01:30

Introduction to Structures

1.8K
A structure is defined as a system of interconnected members designed to support or transfer forces and successfully withstand the loads acting on them. The internal forces of a structure can be determined by decomposing the structure and analyzing the free-body diagrams of the individual members or of a combination of members. This helps in understanding the structural elements' behavior and ensuring that the structure is stable and can withstand the subjected loads.
There are three main...
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Simple Trusses01:21

Simple Trusses

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A truss is a structural framework consisting of slender members connected at joints, designed to support external loads while minimizing material usage and weight. Simple trusses are a type of planar truss where all members lie within a single two-dimensional plane.
The most basic planar truss is a simple truss with three members arranged in a triangular formation. This triangular truss is inherently stable and rigid due to its geometry, making it an ideal starting point for creating more...
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Stability of structures01:14

Stability of structures

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In mechanical engineering, the stability of systems under various forces is critical for designing durable and efficient structures. One fundamental way to explore these concepts is by analyzing systems like two rods connected at a pivot point, O, with a torsional spring of spring constant k at the pivot point. This system is similar in appearance to a scissor jack used to change tires on a car. In this case, the arms of the linkage (equivalent to the rods in this system) are entirely vertical,...
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Space Trusses01:25

Space Trusses

1.4K
A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. The space truss is widely used in various construction projects due to its adaptability and capacity to withstand complex loads.
At the core of a space truss lies the fundamental unit known as the tetrahedron. This structure is composed of six members that form a three-dimensional shape...
1.4K
Frames01:30

Frames

863
Frames are essential components of various mechanical and structural systems used daily. These structures are known for their stability and ability to bear heavy loads. A frame is constructed using two-force and multi-force members, interconnected using pin joints. In contrast, trusses are made entirely of two-force members.
Frames are versatile and widely used in various applications such as structural supports for beams and columns, automobile chassis construction, and in the construction...
863
Space Trusses: Problem Solving01:29

Space Trusses: Problem Solving

945
A space truss is a three-dimensional counterpart of a planar truss. These structures consist of members connected at their ends, often utilizing ball-and-socket joints to create a stable and versatile framework. Due to its adaptability and capacity to withstand complex loads, the space truss is widely used in various construction projects.
Consider a tripod consisting of a tetrahedral space truss with a ball-and-socket joint at C. Suppose the height and lengths of the horizontal and vertical...
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Related Experiment Video

Updated: Mar 11, 2026

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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Tau Structures.

Jesus Avila1, Juan S Jiménez2, Carmen L Sayas3

  • 1Centro de Biología Molecular Severo Ochoa (Consejo Superior de Investigaciones Científicas-UAM)Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades NeurodegenerativasMadrid, Spain.

Frontiers in Aging Neuroscience
|November 24, 2016
PubMed
Summary
This summary is machine-generated.

This review details the structures of tau protein, a key player in neuron function. Understanding tau

Keywords:
PHFsaggregationmicrotubule-associated proteinsmotifsposttranslational modificationstau residuestubuling binding

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Area of Science:

  • Neuroscience and Molecular Biology
  • Focus on protein structure and function

Background:

  • Tau protein is crucial for microtubule stability, neuronal development, and polarity.
  • Dysregulation of tau is implicated in various neurological disorders.

Approach:

  • Comprehensive review of tau protein structure at primary, secondary, tertiary, and quaternary levels.
  • Analysis of tau conformation from individual residues to dimers, oligomers, and polymers.
  • Examination of structural changes in both physiological and pathological contexts.

Key Points:

  • Detailed exploration of tau's molecular architecture.
  • Correlation between tau structure and its role in neuronal health and disease.
  • Insights into the formation of tau aggregates.

Conclusions:

  • A thorough understanding of tau structure is vital for deciphering its physiological roles and pathological mechanisms.
  • This review provides a structural framework for future research into tauopathies.